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Be polite and firm, but don’t over explain. 2. Avoid a confrontation. However, while we were saying our goodbyes to our friends in Niue, we noticed that the ship wasn’t at the harbor. Keep in mind, this is an island of about 1,200 people where no boats are anchored in the harbor. Ships don’t easily “disappear.” We asked a few folks who worked for Niue tourism, “What happened to the large ship that was here?” “It’s gone!” they said.

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Structure of the MECP2 gene and mRNA (adapted from Kriaucionis and Bird,30 and Mnatzakanian et al31). Alternative splicing for the A ( isoform is shown above the gene and for the B ( isoform below the gene. The B isoform has the highest expression in brain, and mutations specific to this isoform are sufficient to cause RS.31 (B) Structure of the B isoform MeCP2 protein sequence.